Abstract General Information

Title

CLINICAL CHARACTERISTICS AND PSYCHOLOGICAL AND BEHAVIORAL PROBLEMS IN CHILDREN WITH FAMILY PRIMARY NOCTURNAL ENURESIS

Introduction and objective

Primary nocturnal enuresis (PNE) is common in clinic, and some children with primary nocturnal enuresis have family genetic history, but there are few studies on family primary nocturnal enuresis (FPNE). The purpose of this study is to analyze the clinical characteristics, psychological and behavioral abnormalities of children with family primary nocturnal enuresis, so as to provide reference basis for clinical treatment and psychological intervention.

Method

The clinical information of 306 children with primary enuresis (PNE) collected from the enuresis clinic of the first affiliated Hospital of Zhengzhou University and the first affiliated Hospital of Xinxiang Medical University from September 2019 to September 2022, included general information questionnaire, voiding diary, Rosenberg self-esteem scale (SES), strengths and difficulties questionnaire and children's sleep questionnaire. Children with PNE were divided into family primary nocturnal enuresis group (FPNE group, n = 45) and sporadic primary nocturnal enuresis group (SPNE group, n = 261), according to whether three generations of family members were involved or not. The clinical characteristics, psychological and behavioral changes of FPNE group were analyzed.

Results

The incidences of severe NE、non-monosymptomatic nocturnal enuresis (NMNE).、abnormal stool and nocturnal micturition ≥ 2 times in the FPNE group were (68%、75%、48% and 29%, respectively)significantly higher than the sporadic enuresis group (SPNE group)(57%、47%、24% and 11%, respectively). The number of enuresis children aged 13-16 years old in FPNE group was 44.4% (20/45), which was significantly higher than 19.6% in the SPNE group(50/261) (P < 0.05). The daytime voiding frequency, maximum voided volume and nocturnal urine volume in FPNE group were higher than those in SPNE group (P < 0.05). In the FPNE group, 46.7% (21/45) children were autosomal dominant, 33.3% (15/45) children were autosomal stealth inheritance, and 20.0% (9/45) children showed polygenic inheritance. The total scores of emotional symptoms、hyperactivity symptoms and difficulties in the FPNE group were higher than those in the SPNE group(P < 0.05). There was no significant difference in the scores of conduct problems, peer communication and society between the two groups(P＞0.05).

Conclusion

There are many ways of inheritance of FPNE, among which autosomal dominant inheritance is the most common, the incidence of psychological symptoms and hyperactive symptoms is high, and the clinical symptoms are more serious, the risk of frequent and urgent urination is higher, and it is not easy to cure with age. Therefore, enuresis children with positive family history should be evaluated in time, intervened as soon as possible and treated accurately.